Senior Research Scientist---Drug Metabolism
Texas Southern University

Job Info

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Security Sensitive Position?:

Yes

Hours of Work:

8:00 AM - 5:00 PM M-F

Posting Number:

TSU203254

Official TSU Title:

Senior Research Scientist---Drug Metabolism

Grant Title:

Senior Research Scientist---Drug Metabolism

Job Description Summary / TWC Summary:

Under direct supervision of U54 grant PIs/PD and Research Infrastructure Core Director, conducts in vitro and in vivo ADME studies in drug development in the Center for Biomedical and Minority Health Research (CBMHR). Specifically, responsible for small and large molecules quantification drug metabolite identification, drug absorption using the Caco-2 cell culture model, intestinal perfusion model and portal vein infusion model, drug metabolism using enzyme-mediated models, drug elimination and bio-distribution using animal models, providing the relevant services and technical support to internal and external users. In addition, the Sr. Research Scientist is responsible for supporting the research and development activities of the university's large center grants, including the NIH U54 RCMI-CBMHR Center, CPRIT CCPF Center, the iD3 Center, and TSU's Catalyst, writing grants and scientific papers, presenting research results at local, national, and international meetings, helping faculty members to guide graduate students, and maintaining instruments and managing the labs.

This is a Grant Funded position.

Essential Duties Summary:

• Responsible for operating, maintaining instruments and conducting bioanalysis using Waters UPLC and Sciex 4000/6500/7500 and X500B LC-MS/MS studies in the RCMI-CBMHR core facility.
• Conduct RCMI drug absorption studies using the Caco-2 cell culture, transporter vesicle membrane, intestinal perfusion, and portal vein infusion models including study design, execution of various experiments, data collection, data interpretation, laboratory supplies, and daily operations of the lab
• Conduct in drug metabolism studies including preparing microsomes from tissues and microsomes-mediated in vitro metabolism.
• Caco-2 monolayer cell culture for in vitro ADME studies.
• Conduct PK studies using rodents and PK/PD modeling analysis.
• Maintains all CBMHR instruments, develops and implements record-keeping systems on program participants, staff, equipment inventories and compliance activities. Provide direct support to the RCMI grant leadership, RCMI project faculty and professional staff members. Prepares facility activity reports and program status to the users, university and funding agency.
• Assist PIs in progress report of various projects and progress reports.
• Publishes data, presents at conferences and seeks external funding.
• Trains Undergraduate and Graduate students in research skills.
• Performs other job-related duties as assigned

% FTE:

1.0

Hiring Range:

$64,197.37 - $81,851.64

Education:

Doctoral degree in biomedical science-related field with experience in pharmaceutical research laboratory.

Minimum education as required.

Required Licensing/Certification:

None required.

Knowledge, Skills, and Abilities:

Knowledge of:

• Requires a minimum of 4 years' experience in pharmaceutical laboratory research including drug absorption, drug metabolism, bioanalysis, PK studies and analysis, and cell culture.
• Requires seasoned skills in the job function or professional discipline; performs more complex but expected work for a fully competent incumbent in the function or discipline; demonstrates an understanding of most work routines, rules, procedures and operations; some contact with others, including students, general public, visitors and University personnel to provide or obtain explanation or additional information
• Biostatistical analysis supporting pharmaceutical research.
• Technical and functional principles and procedures.
• Microsoft Office Professional or similar applications.

Skill in:

• Detail oriented.
• Problem-solving and decision-making.
• Multitasking and time management.
• Writing documents.
• Both verbal and written communication.

Ability to:

• Requires moderate interpersonal and communication skills to ensure that customer requests or needs are met. Acknowledges and clarifies customer inquiries, requests, or complaints to ensure that needs are identified, documented and addressed.
• Operating and maintaining instruments; providing service and technical support to internal and external users; providing direct support to the CBMHR leadership, faculty, users and staff members; submitting reports, publishing and presenting data, and applying for funding.
• Performs tasks and duties under general supervision, using established procedures and some innovation. Chooses from alternatives to resolve problems. Independent judgment is required to complete work assignments. Often makes recommendations to work procedures, policies and practices. Refers unusual problems to supervisor.

Work Experience:

Requires a minimum of 4 years of experience in analytical method development, drug absorption and metabolism studies, PK analysis, LC-MS/MS system operation. Preferred experience in drug formulations.

Working/Environmental Conditions:

Work is performed within routine office environment with no exposure to hazardous or unpleasant conditions. Physical demands are usually limited to sitting or standing in one location much of the time. Some stooping, lifting or carrying objects of light weight may be required.

UA EEO Statement:

It is the policy of Texas Southern University to provide a work environment that is free from discrimination for all persons regardless of race, color, religion, sex, age, national origin, individuals with disability, sexual orientation, or protected veteran status in its programs, activities, admissions or employment policies. This policy of equal opportunity is strictly observed in all University employment-related activities such as advertising, recruiting, interviewing, testing, employment training, compensation, promotion, termination, and employment benefits. This policy expressly prohibits harassment and discrimination in employment based on race, color, religion, gender, gender identity, genetic history, national origin, individuals with disability, age, citizenship status, or protected veteran status. This policy shall be adhered to in accordance with the provisions of all applicable federal, state and local laws, including, but not limited to, Title VII of the Civil Rights Act.

Manual of Administrative Policies and Procedures

Close Date:

11/26/2024

Open Until Filled (overrides close field) :

No

Special Instructions to Applicants:

Open to all applicants.

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