Scientist, Metabolomics
AstraZeneca

Job Info

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At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges. We do this with the upmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. As a part of our Dynamic Omics team in Gaithersburg, MD, you'll play a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients' lives!

About AstraZeneca in Gaithersburg, MD

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while growing collaboration between teams.

Summary of the Group

Dynamic Omics is part of the Centre of Genomics Research/Discovery Sciences within AstraZeneca, and works across all therapeutic areas (Oncology, Cardiovascular, Renal and Metabolism (CVRM), Respiratory and Immunology (RI), Vaccines and Immunotherapies and Neurosciences). The team delivers key data to projects across all phases of drug discovery and development, and we work with all modalities from small molecules to biologics. As a member of the growing Dynamic Omics department, you will be actively involved in analyzing preclinical and clinical samples using metabolomics and lipidomics workflows and sophisticated bioinformatics.

Accountabilities:

This role is laboratory-based and will require bio-specimen handling, preparation, and ability to operate and maintain mass spectrometers and ensure data is accurately acquired and analyzed. The successful candidate will have the opportunity to work and grow in a fast-paced matrix environment under the supervision of senior staff members.

Essential Skills/Experience

• Masters Degree or equivalent experience or equivalent in analytical chemistry, mass spectrometry, metabolomics, or other relevant scientific field with 2+ years' experience.
  
• Must have prior hands-on experience in metabolomics and LC-based mass spectrometry (RP and HILIC; ideally Thermo Tribrid platform, Agilent qTOF, 908 devices CZE; SPE and ion mobility is a plus).
  
• Operate instruments, process samples, design experiments, analyze data, interpret experimental results, and summarize data for presentations and reports with accountability for accuracy.
  
• Experience with an entire metabolomics pipeline (including sample preparation, QA/QC, LC and MS operation, data analysis) and able to conduct research independently of a SOP.
  
• Excellent teammate with collaboration and interpersonal skills, both verbal and written; demonstrates passion, motivation, and attention to detail.
  
• Strong laboratory leadership skills - multi-tasking, time management, and organization.
  

Desirable Skills/Experience:

• PhD in analytical chemistry, mass spectrometry, or metabolomics, or other relevant scientific field with 0+ years' experience
  
• Experience in R data analysis is highly desired, including R shiny.
  
• Experience working with/creating spectral libraries and/or implementing metabolite/lipid annotation methods.
  
• Experience with network analysis and multi-omic data integration.
  
• Experience with robotic automation, SPE, and high-throughput sample processing.
  
• Ability to collaborate across multiple fields to investigate drug candidates and disease mechanisms.
  
• Familiar with Human Biological Sample standard processes - handing, compliance, and due diligence.
  

Why AstraZeneca

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available, and we hope it's yours.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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