Scientist, Histologist - Pathology CPSS
AstraZeneca

Job Info

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Are you passionate about high-quality histology and eager to support advanced pathology imaging and digital image analysis in drug discovery? Do you have expertise in applying sophisticated algorithms and image analysis techniques to complex tissue imaging data? If so, we invite you to explore this exciting opportunity in our Imaging and Data Analytics Pathology department at AstraZeneca!

The Role

As an Image Analysis Scientist, you will play a crucial role in drug discovery by delivering the histology components of early investigative safety studies. Your responsibilities will include tissue trimming, processing, precision microtomy, staining, and digitization. You will independently manage the entire histology process and develop image analysis algorithms using both commercial software platforms and custom computer vision models, primarily for digital pathology imaging modalities (e.g., H&E, IHC, multiplex immunofluorescence) across various therapeutic areas.

You will collaborate with a multidisciplinary team, including imaging scientists, pathologists, biologists, and data scientists within Clinical Pharmacology and Safety Sciences (CPSS). Your work will contribute to deriving biological insights from digital pathology imaging data, ultimately supporting our drug development projects.

Key Responsibilities:

• Drive impactful contributions to drug projects through comprehensive image analysis support across all AZ therapeutic areas.
• Develop and deliver computer vision and image analysis solutions for digital pathology imaging activities in preclinical studies (e.g., positive cell count, tissue segmentation).
• Collaborate globally with imaging scientists, pathologists, and other image analysis experts to define analysis plans and derive features from imaging data.
• Engage with local and global image analysis communities, building collaborative networks.
• Perform routine and non-routine histology tasks, including tissue trimming, sample processing, embedding, microtomy, and staining (H&E and immunohistochemistry).
• Ensure high-quality slide digitization and manage human tissue samples in accordance with company guidelines.
• Analyze data, interpret results, and communicate findings clearly to team members and stakeholders.
• Maintain compliance with GXP regulations and stay current with relevant training.
• Contribute to scientific manuscripts, presentations, and patent applications as needed.

Essential Requirements:

• Bachelor's degree in a relevant field (biomedical sciences, molecular biology, biotechnology, etc.).
• Extensive experience in histology, including tissue preparation, processing, and microtomy.
• Knowledge of immunohistochemistry, immunofluorescence, or in situ hybridization.
• Strong skills in experimental design, critical data analysis (including statistics), and reporting.
• Comprehensive understanding of histology techniques and molecular pathology data analysis.
• Experience in the pharmaceutical industry or a molecular pathology laboratory is preferred.
• Familiarity with automated IHC staining platforms and immunohistochemistry methodology.

Why AstraZeneca?

At AstraZeneca, we are revolutionizing the integration of imaging technologies to provide unparalleled insights in drug discovery. This role offers the unique opportunity to investigate both the safety and efficacy of new drugs in preclinical and clinical settings. Join us in our mission to deliver life-changing medicines to patients!

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being daring - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering groundbreaking methods, and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next?

Are you ready to bring new insights and fresh thinking to the table? We have one seat available, and we hope it's yours.

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/

Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/

Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en

The annual base pay (or hourly rate of compensation) for this position ranges from $83,249.60 to $124,874.40, either as annual base pay or as the hourly rate (annual base pay divided by 2080 hours)]. Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an "at-will position" and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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