Principal Scientist Medicinal Chemistry
AstraZeneca

Job Info

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Introduction to role:

Are you ready to lead small molecule projects as the Medicinal Chemistry project leader? We're looking for a Principal Scientist to provide scientific leadership of PhD and BS/MS level internal medicinal chemistry and CRO resources. You'll have the opportunity to provide wider project and strategic feedback to the rapidly growing small molecule portfolio!

Accountabilities:

Lead small molecule multidisciplinary projects with internal and external medicinal chemistry resources. You'll be accountable for design strategy and deliverables in lead optimization and lead generation phases. You'll work closely with biology project leads, DMPK project leads, and other scientists in small molecule research to deliver development candidates for various targets. You'll also serve as a subject matter expert in chemistry with internal and external partners and provide recommendations regarding new targets and emerging external opportunities as needed.

Essential Skills/Experience:

• Ph.D. in synthetic organic or medicinal chemistry with 10 plus years of drug discovery experience
• Specific experience leading projects from inception to development candidate nomination in a pharmaceutical and/or biotechnology setting
• Experience scientifically leading internal and external chemistry resources as a project leader without line manager authority
• Excellent communication, leadership, collaboration and interpersonal skills
• Strong track record of innovation demonstrated by patent inventorship, peer-reviewed publications, and conference presentations
• Experience in hit identification techniques and progressing compounds from hit identification to development candidates
• Extensive CRO management experience
• Experience in structure-based drug design with strong design hypothesis

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work five days per week on-site in the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca, we bring patients closer. Everything we do is led by their lived experience, driving what we do and how we do it. We know our patients by name, we meet their families and their careers. Curious, co-creative, attentive and close to each one, razor focused on their needs so we can tackle the toughest challenges for them.

Joining Alexion, AstraZeneca, Rare Disease means embracing an opportunity where work isn't ordinary, in a company where 'Here it means more' is more than a statement, it's an ethos. We are a beacon in the global Biopharmaceutical landscape. Our closeness to patients brings us closer to our work and closer to each other. Combined with our brave, pioneering spirit - we are truly unique in R&D and healthcare.

Ready to make a difference? Apply today!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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